Physical Examination • A careful gynecologic, pelvic and rectal examination is performed to assess the local spread of the cancer. • Examination of the lymph nodes in the groin and neck and an abdominal examination are important to detect masses. Blood and Other Tests • Complete blood count (CBC). • Serum alpha-fetoprotein (for an endodermal sinus tumor). • Serum kidney and liver function tests . Imaging • Chest x-ray. • CT scan of the pelvis and abdomen. • MRI of the pelvis. Endoscopy and Biopsy • Cystourethroscopy. • Proctosigmoidoscopy. • The cancer is confirmed by a vaginal biopsy.